The concept of white matter diseases is considered a white substance diseases that affect the tissues that surround neurons in the brain and spinal cord. These diseases cause damage to nerve fibers, which leads to a group of symptoms, including poor motor coordination and learning difficulties. The date of discovery and diagnosis the date of the discovery of these diseases dates back to the nineteenth century, where scientists began to understand the relationship between white matter and nervous performance. In recent years, diagnostic techniques such as MRI have evolved, which helped doctors identify these cases more accurately. These developments contributed to improving the methods of treatment and care provided to patients.