Cupramine™ effectively eradicates Oodinium, Cryptocaryon, Amyloodinium, Ichthyophthirius, and other ectoparasites of both freshwater and marine fish. It is superior to copper sulfate, chloride & citrate: it is non-acidic, less toxic to fish, remains in solution, and does not contaminate the filter bed. It is superior to chelates: it is fully charged (ionic), active at low concentrations, and is removable with carbon. There is more than a four-fold concentration gap between the minimal therapeutic dose (0.2 mg/L) and the toxic dose (0.8 mg/L). Cupramine™ is easily removable with chemical filtration. It is highly effective and safe in freshwater as well as marine water.